Xeroderma pigmentosum
Xeroderma pigmentosum (XP) is a rare autosomal recessive DNA repair disorder characterized by enhanced UVR sensitivity, early pigmentary alterations, UVR-induced skin and mucous membrane malignancies, and, in some cases, progressive dementia.…
Unilateral Laterothoracic Exanthem
What is Unilateral laterothoracic exanthem?
It is an uncommon condition characterized by a unilateral, periflexural rash that starts from the axilla or groin and can spread to the face, genitalia or hands. The lesions are red,…
Papillon-Lefèvre Syndrome
Papillon-Lefèvre syndrome (PLS) is a rare genetic condition that affects children between the ages of one and five. It is inherited in an autosomal recessive manner. It results from alterations of the CTSC gene; which regulates the production …
Hemangioma and PHACES Syndrome:
Hemangioma is the most common benign vascular tumor of infancy. It is more common among baby girls than boys (3:1). Low birth-weight, advanced maternal age, multiple pregnancy (twins and triplets), placenta previa and preeclampsia are…
Epidermolysis bullosa (EB)
Epidermolysis bullosa (EB) is a group of genetic disorders characterized by skin fragility. Patients with EB are prone to developing blisters on their skin and mucous membranes. These blisters can appear anywhere, but most commonly on areas…
Ichthyosis Vulgaris
The most prevalent of the ichthyoses is ichthyosis vulgaris, a heterogeneous collection of inherited keratinization disorders characterized by extensive scaling of the skin of different severity. Pathogenic mutations in the…
Id Reaction
Id reaction or autosensitization dermatitis is an immunological reaction that occurs in response to a distant localized inflammatory/infectious skin condition. It most commonly occurs in response to a local fungal infection occurring …
How to Avoid Rosacea Triggers
Rosacea is a skin disease that causes erythema to form across the nose and cheeks. In addition to medical therapy, rosacea patients can improve their remission by identifying and avoiding common environmental factors that may trigger f…
Steven-Johnson Syndrome (SJS) and Toxic epidermal necrolysis (TEN)
Introduction:
SJS and TEN are rare, acute, and potentially fatal reactions affecting the skin and the mucous membrane. The evidence suggests that both SJS and TEN result from a defect in detoxifying drug metabolites, inducing immune responses.…
Cutaneous Squamous Cell Carcinoma
Cutaneous squamous cell carcinoma (cSCC) is a malignant skin tumor that arises from the epidermal keratinocytes. They can develop on any cutaneous surface, including the head, neck, trunk, extremities, oral mucosa, periungual skin,…
Cutaneous Leishmaniasis
Leishmaniasis is a parasitic disease transmitted by the bite of infected female sandflies. It is caused by more than 20 species of Leishmania which is a flagellated protozoa.
Epidemiology:
- Worldwide, there are approximately …
Morphea
Morphea is an autoimmune connective tissue disorder, which is characterized by the hardening of the skin. It is a relatively uncommon disorder as the annual incidence rate is estimated to be 27 per million; however, the prevalence increases…