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Pachyonychia congenita

Pachyonychia congenita is a rare inherited disorder of keratinization that primarily affects the nails and skin. Affected people develop thickened skin on the soles and palms, white patches on the tongue and mouth, and bumps around the elbow…
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Pachyonychia Congenita

  Pachyonychia congenita is a rare inherited disorder of keratinization that primarily affects the nails and skin. Affected people develop thickened skin on the soles and palms, white patches on the tongue and mouth, and bumps around…
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Xeroderma pigmentosum

Xeroderma pigmentosum (XP) is a rare autosomal recessive DNA repair disorder characterized by enhanced UVR sensitivity, early pigmentary alterations, UVR-induced skin and mucous membrane malignancies, and, in some cases, progressive dementia.…
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Unilateral Laterothoracic Exanthem

  What is Unilateral laterothoracic exanthem? It is an uncommon condition characterized by a unilateral, periflexural rash that starts from the axilla or groin and can spread to the face, genitalia or hands. The lesions are red,…
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Papillon-Lefèvre Syndrome

Papillon-Lefèvre syndrome (PLS) is a rare genetic condition that affects children between the ages of one and five. It is inherited in an autosomal recessive manner. It results from alterations of the CTSC gene; which regulates the production …
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Hemangioma and PHACES Syndrome:

Hemangioma is the most common benign vascular tumor of infancy. It is more common among baby girls than boys (3:1). Low birth-weight, advanced maternal age, multiple pregnancy (twins and triplets), placenta previa and preeclampsia are…
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Epidermolysis bullosa (EB)

Epidermolysis bullosa (EB) is a group of genetic disorders characterized by skin fragility. Patients with EB are prone to developing blisters on their skin and mucous membranes. These blisters can appear anywhere, but most commonly on areas…
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Ichthyosis Vulgaris

    The most prevalent of the ichthyoses is ichthyosis vulgaris, a heterogeneous collection of inherited keratinization disorders characterized by extensive scaling of the skin of different severity. Pathogenic mutations in the…
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Id Reaction

  Id reaction or autosensitization dermatitis is an immunological reaction that occurs in response to a distant localized inflammatory/infectious skin condition. It most commonly occurs in response to a local fungal infection occurring …
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How to Avoid Rosacea Triggers

  Rosacea is a skin disease that causes erythema to form across the nose and cheeks. In addition to medical therapy, rosacea patients can improve their remission by identifying and avoiding common environmental factors that may trigger f…
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Steven-Johnson Syndrome (SJS) and Toxic epidermal necrolysis (TEN)

Introduction: SJS and TEN are rare, acute, and potentially fatal reactions affecting the skin and the mucous membrane. The evidence suggests that both SJS and TEN result from a defect in detoxifying drug metabolites, inducing immune responses.…
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Cutaneous Squamous Cell Carcinoma

  Cutaneous squamous cell carcinoma (cSCC) is a malignant skin tumor that arises from the epidermal keratinocytes. They can develop on any cutaneous surface, including the head, neck, trunk, extremities, oral mucosa, periungual skin,…