Onychomycosis


Onychomycosis is a fungal infection of the nail caused by dermatophytes, non-dermatophyte molds, and yeasts (mainly Candida species). Incidence increases with age, and it rarely occurs in children. Dermatophytes (Trichophyton rubrum) account for 80% of toenail infections. Onychomycosis is categorized clinically as distal and lateral subungual onychomycosis (DLSO), superficial white onychomycosis (SWO), proximal subungual onychomycosis (PSO), candida onychomycosis, and total dystrophic onychomycosis. Diagnosis of onychomycosis involves physical, microscopic examination and culture. Histologic evaluation using PAS staining is a sensitive method for detecting onychomycosis. Moreover, eradication of the infection is important to improving the cosmetical appearance and avoiding complications. However, it is not simply accomplished because nails are made of hard keratin, which is avascular and resistant to many agents. Thus, creams and other topical medications are commonly not effective against nail fungus. Treatment results take up to a year to appear because nails have poor drug delivery. Treatment differs depending on the severity of nail changes, the involved organism, and adverse effects. Clinical cure refers to improvement in the nail’s appearance, often described as a normal appearance in 80% to 100% of the nail. Usually, effective treatment is achieved by systemic antifungal therapy. Antifungals from the allylamine and azole classes are the most widely used oral medications to treat onychomycosis. The azole class includes itraconazole, fluconazole, and ketoconazole; however, ketoconazole is seldom prescribed because of hepatotoxicity and drug interactions. Itraconazole is prescribed in “pulse doses” one week per month for 2 or 3 months. It can interact with erythromycin or asthma medications. Furthermore, itraconazole’s most frequent side effects include gastrointestinal side effects, transaminitis, high lipids, and skin rash. The allylamine class is represented by terbinafine. Terbinafine is taken daily for eight weeks for fingernail fungus and 12 weeks for toenail fungus. The most frequent side effects are gastrointestinal disturbance, headache, and transaminitis.

Written By: Dr. Fatimah Alowirdi, Dermatology Resident

References:

https://dermnetnz.org/topics/fungal-nail-infections/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88888/

 

Dermatomyositis

 

 

Dermatomyositis is a rare disease that causes muscle inflammation and skin rash.

It can occur at any age, but it most often affects adults over the age of 50, the exact cause is not known but is thought to be an autoimmune disorders, with genetic predisposition and environmental factors that might play a role.

 

symptoms are caused by swelling and inflammation in the blood vessels that supply the skin and muscle scan appear suddenly or develop gradually over time most commonly a violet-colored or dusky red rash develops on the face and eyelids(heliotrope rash), knuckles (guttron’s sign), elbows, knees, chest and back(shawl sign). The rash can be itchy and painful.Muscle changes usually develops after the rash ,muscles are stiff and tender which make it difficult to do things like brushing hair ,walking upstairs and lifting legs.

 

Dermatomyositis might cause other conditions including Raynaud’s phenomenonwhen  fingersturn pale when exposed to cold temperature,cardiovascular diseases, lung diseases and increased likelihood of developing cancer.

 

Diagnosis of dermatomyositis is based on person’s medical history and a physical exam, also by ordering blood tests to look for autoantibodies. muscle biopsy, Electromyography, and imaging screening for underlying cancer.

 

There’s no cure for dermatomyositis, but treatment aim is to improveskin rash and muscle strength and functionwith medications like corticosteroid and steroid sparing agents, also general measures including sun protection and regular exercises.

 

 

Written by:

Yasmeen Alanazi, Dermatology resident, King Fahad Medical City.

 

References:

bad.org.uk

dermnetnz.org

Vitiligo: classification ,severity scoring system and psychosocial impact

 

 

The Vitiligo European Taskforce came to a consensus about the classification of vitiligo in 2007.

They decided on four main categories with subtypes. Classification  Subtype  Comments 
Nonsegmental vitiligo   Focal 

 Mucosal 

 Acrofacial 

 Generalised 

 Universal 

bilateral and symmetrical in distribution. 

Stable or unstable 

Segmental vitiligo   Focal 

 Mucosal 

 Unisegmental, bi- or multisegmental 

Single white patch in 90% 

Border often irregular 

Affects young people 

Stable 

Cutaneous mosaicism 

Mixed vitiligo   Nonsegmental combined with segmental vitiligo  Rare 
Unclassified vitiligo   Focal at onset 

 Multifocal asymmetrical non-segmental 

 Unifocal mucosal 

Early disease 

 At least two scoring systems have been devised for vitiligo and are used in clinical trials. 

 Vitiligo Area Scoring Index (VASI) 

 Vitiligo European Task Force (VETF) system 

 

VASI : It measures the extent and degree of depigmentation in 6 sites: hands, upper extremities, trunk, lower extremities and feet, head/neck. 

VETF: The VETF assesses the extent, staging and spreading/progression in 5 sites: head/neck, trunk, arms, legs and hands/feet. It grades from 0 (normal pigmentation) to 4 (complete hair whitening). Spreading is assessed using the following scores: 0 (stable disease), -1 (regressive disease) and +1 (progressive disease) 

 

Because vitiligo affects a person’s physical appearance, there are various associated psychological and social impacts. Higher levels of depression and social anxiety have been reported in patients with vitiligo. Patients may also experience low self-esteem, social stigmatization, shame, avoidance of intimacy, adjustment disorder, fear, suicidal ideation, and other psychiatric morbidities .Family support, counselling and cognitive behavioural treatment can be of benefit. 

 

 

Written by: Abdul Aziz Al-mufadhi, PGY1 Dermatology Resident 

 

Resources: 

www.DermNetNZ.org 

https://www.medscape.com/ 

bolognia dermatology 4th edition 

Sunscreen Awareness Month

 

Introduction: 

According to the American Academy of Dermatology Association, May is Skin Cancer Awareness Month, and May 28 is National Sunscreen Day, by the early 20-century sunscreen started to manufacture and by the mid-1970s that sunscreens gained a degree of consumer acceptance, which help and prevent a variety of dermatological conditions. 

How to have optimal sun protection 

To have good sunscreen: 

Broad-spectrum sunscreen= UVA + UVB protection 

Water resistance = maintenance of SPF after 40 or 80 minutes in water. 

SPF ≥ 15 or 30 recommended. 

Re-apply1-2 hours during outdoor activates 

Other measures: 

Staying in the shade especially from 10 AM – 2 PM 

Wide brim hats 

Sunglasses 

Protective clothing 

Types of sunscreens: Chemical  Physical 
works like a sponge on the surface of your skin, absorbing the sun’s rays.  works like a shield on the surface of your skin, deflecting the sun’s rays. 
Optimal if you have sensitive skin  Easier to rub in the skin without leaving residue 
Example: zinc oxide, titanium dioxide  oxybenzone, avobenzone, and ecamsule 

 Concentrations as are utilized in SPF testing is: 2 mg/cm2 to achieve 2 mg/cm2 of density: 

1 teaspoon of sunscreen to the face/head/neck 

1 teaspoon to each upper extremity 

2 teaspoons to the front and back torso 

2 teaspoons to each lower extremity 

Benefits of sunscreen: 

Reduce the onset of Photoaging 

Photo immune Suppression 

Non-melanoma Skin cancer 

Photosensitivity Disorders 

 

Written by: Abdullah Nasser Al-Omair, Dermatology Resident

Reference: UpToDate

Psoriasis Awareness Month

 

August is National Psoriasis Awareness Month, which gives us the opportunity to educate the public about it. The below article elicits some information about psoriasis definition, causes, presentation, and treatment.

 

Psoriasis is a dermatologic condition that makes the skin red, thick, and flaky. It is usually pink/salmon colored skin areas covered with silver or white scales. However, in darker skin tones, the psoriasis spots are purple, dark brown, or dark grey. It is mainly an adult disease, but it can develop in both children and adolescents. Both males and females are equally affected. It is not a contagious disease, because it is not an infection.

 

The exact cause behind psoriasis is yet to be identified. One of the important players in developing psoriasis is the immune system. The skin is made up of several layers; the top layer is the epidermis, and it has cells that divide rapidly and eventually die forming a layer of dead cells called the stratum corneum. In skin affected by psoriasis, immune cells enter the skin through blood vessels and cause the epidermis to grow very rapidly and to stop shedding properly.

 

The second player behind developing psoriasis is genetics. About 40% of people with psoriasis have family members with the disorder. Several genes have been identified to make people more susceptible to psoriasis. Some specific environmental and behavioral factors have been identified to be linked to psoriasis. Bacterial and viral infections, alcohol consumption, and some medications may affect the person’s risk of developing psoriasis or worsen the symptoms.

 

The symptoms of psoriasis include dry, red, or dark areas covered with white or silvery flakes. It can be on the scalp, elbows, genitals, or skin folds. It can be itchy or associated with skin pain. Joint swelling, pain, or stiffness. Nails can be affected too, and look pitted crumbly, or different in color. There are multiple types of psoriasis, however, the most common form is plaque psoriasis. It mainly affects young and middle-aged adults. Each skin plaque or spot is usually between 1-10 cm. It can appear on the scalp, elbows, knees, and back.  

 

The disease course is usually lifelong as it is currently not curable. However, the severity of the disease can improve or worsen over time, and it is controllable by treatment.

 

Patients with psoriasis are affected emotionally as well. As people with the condition might feel embarrassed of their skin. They might get depressed or anxious. Working with a psychologist is often helpful.

 

The diagnosis is usually made by examining the skin, only occasionally a skin biopsy or scraping is required. The treatment is mainly to control the symptoms. It varies based on the severity of the psoriasis. It includes various topical, oral, or injectable medications.

 

 

Written by: Ghada Alhayaza, PGY-1 Dermatology Resident

 

Resources:

Uptodate

Vitamin D in Acne

 

 

  Vitamin D is a fat-soluble hormone found in the body that serves many purposes, most famously bone formation. Although vitamin D is most important for bone health, it also plays a key role in many of the body’s other functions including but not limited to; antimicrobial, antiproliferative, anti comedogenic, and antioxidative processes. Vitamin D is gained through diet, supplements, and exposure to sunlight. In regards to dermatologic diseases, and more specifically in the treatment of acne vulgaris, the antimicrobial properties of vitamin D have been an interesting area of research in recent years.

 

  It has been established that acne vulgaris patients were more likely to have deficient vitamin D levels than controls. Variable associations have been made between the severity of acne lesions and deficient vitamin D levels, although some studies have shown improvement in inflammatory acne lesions when patients were given vitamin D supplementation. This improvement is restricted to inflammatory lesions, while non-inflammatory lesions showed no improvement. This could be due to vitamin D’s antimicrobial properties, as inflammation caused by propionibacterium acnes is significant to the pathogenesis of acne vulgaris. Another association between vitamin D levels and acne vulgaris is linked to sebaceous gland activity, in which it was found that lower levels of vitamin D stimulate lipogenesis in sebaceous glands. The increased lipogenesis promotes inflammatory lesions in acne vulgaris.

 

 These findings open the door to the possibility of using topical vitamin D analogues in the treatment of acne, as well as screening acne vulgaris patients for Vitamin D deficiency. As of today, using vitamin D in the treatment of acne is grade B recommendation with IIb level of evidence.

 

 

 

 

Written by: Hadeel Awartani, Medical Student

 

 

Resources:

1-Amal Ahmed Mohamed, Eman Mohamed Salah Ahmed, Rasha T.A. Abdel-Aziz, Halaa H. Eldeeb Abdallah, Hadeel El-Hanafi, Ghada Hussein, Maggie M. Abbassi & Radwa El Borolossy (2020) The impact of active vitamin D administration on the clinical outcomes of acne vulgaris, Journal of Dermatological Treatment, DOI: 10.1080/09546634.2019.1708852

2-Navarro-Triviño FJ, Arias-Santiago S, Gilaberte-Calzada Y. Vitamin D and the Skin: A Review for Dermatologists [Internet]. Actas Dermo-Sifiliográficas (English Edition). Elsevier Doyma; 2019 [cited 2021Apr23]. Available from: https://www.sciencedirect.com/science/article/pii/S157821901930112X

3-Mostafa WZ, Hegazy RA. Vitamin D and the skin: Focus on a complex relationship: A review [Internet]. Journal of advanced research. Elsevier; 2015 [cited 2021Apr23]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642156/

4-Study links vitamin D deficiency with acne [Internet]. Dermatology Times. [cited 2021Apr23]. Available from: https://www.dermatologytimes.com/view/study-links-vitamin-d-deficiency-with-acne

5-Vitamin D for Acne: Benefits, Uses, & Effects of Vitamin D Deficiency [Internet]. Healthline. 2021 [cited 23 April 2021]. Available from: https://www.healthline.com/health/vitamin-d-for-acne

Occupational skin manifestations

 

 

It is possible for some skin manifestations to arise due to an individual’s occupation, some of those occupations include hairdressers, food industry, health care, farmers, construction. Parts affected depend on exposure, mostly hands.

 

An individual’s likelihood of developing occupational skin manifestations includes an individual’s predisposition, hygiene, and exposure. These conditions arise due to exposure to chemicals such as rubber additives, hair dyes, cement, arsenic. Furthermore, biological exposure plays a role as well some of which include contact with an infected human, plants, and animals. In addition to the above, physical exposure may contribute which consist of mechanical trauma, heat, humidity, cold, and radiation. The most common conditions in these individuals are hand dermatitis, mechanical injury, and infections. Some precautions should be taken to prevent such skin manifestations by identifying, minimizing, and eliminating the causes. Moreover, monitoring the workers with relation to the exposure and appropriate treatment when indicated.

 

Occupational skin manifestations are common in wet working environments, for example, hairdressers, food industry, health care workers, and farmers. Steps should be taken to avoid such skin manifestations and injuries.

 

 

 

Written by: Khalid Al Dakheel, Medical Student 

 

Resources:

www.DermNetNZ.org

What is dermaplaning?

 

 

  Dermaplaning is a simple non-invasive outpatient procedure which has gained popularity through social media platforms as an easy way to achieve a smoother skin complexion, remove unwanted hair on the face and prevent acne vulgaris. Although this procedure has only recently become well-known, it has been performed by dermatologists and licensed aestheticians for many years.

 

  Dermaplaning exfoliates the face by using a small scalpel blade to remove dead skin cells from the upper epidermis and facial hair. The removal of this superficial layer of skin offers the cosmetic benefit of achieving a more radiant and even texture complexion, as well as minimizing fine wrinkles and reducing the appearance of acne scars. As with any exfoliating procedure, dermaplaning allows deeper penetration of skin products such as moisturizers and serums which may contribute to the improved appearance of skin post-procedure. This is why dermaplaning may be of great benefit in patients with hyperproliferative disorders such as eczema or psoriasis, as removal of the cellular debris would allow proper penetration of hydrating treatments.

 

  Although dermaplaning is considered a low-risk procedure, it does not come without side effects such as skin hypersensitivity directly after or infection in rare cases. It is advised to apply protective sunscreen to reduce the risk of hyperpigmentation of the new skin layer and apply soothing agents to reduce inflammation.

 

  Despite the renewed public interest, patients should take into consideration the possible risks of dermaplaning especially if they plan to do it themselves. Improper tools or technique may result in injury or infection, and it is best to consult your dermatologist before self-performing this procedure.

 

 

Written by: Hadeel Awartani, Medical Student

 

 

Resources:

1- Dermabrasion and Dermaplaning  https://www.hopkinsmedicine.org/health/wellness-and-prevention/dermabrasion-and-dermaplaning

2- Townsend R (2017) The Use of Advance Dermaplaning in Clinical Skin Care and Treatment. Clin Dermatol Res J 2:2. doi: 10.4172/2576-1439.1000117

3- Dermaplaning: Efficacy, Side Effects, and More https://www.healthline.com/health/beauty-skin-care/dermaplaning

4- Pryor L, Gordon CR, Swanson EW, Reish RG, Horton-Beeman K, Cohen SR. Dermaplaning, topical oxygen, and photodynamic therapy: a systematic review of the literature. Aesthetic Plast Surg. 2011 Dec;35(6):1151-9. doi: 10.1007/s00266-011-9730-z. Epub 2011 May 2. PMID: 21533984.

A Brief History on Modern Clinical Dermatology

 

Scholars date back the start of modern dermatology to November first of the year 1801, with St Louis hospital in France being turned into an exclusively dermatological hospital; which was the catalyst for the rapid interest in dermatology in France at the time. The hospital was a centre for dermatological studies and with its success, it kindled the establishment of other centres in Paris.

 

Physician Jean-Louis Alibert (1736-1837) was made physician in 1803, It is thought that he was responsible for making St Louis Hospital a hospital for skin diseases, due to his high social status.

 

In 1816, Laurent Théodore Biett, was put in charge of the out-patient department of St Louis Hospital, where he made many advances in the field such as creating the Asiatic pill and protiodide and biniodide of mercury for the treatment of syphilis.

 

He also taught the next generation of French dermatologists whom will take over in the next half of the century. Some of which are Cazenave, Gibert, Devergie, and Bazin whose contributions range from adding to the knowledge of tuberculosis at the time, to the treatment of scabies. At that period, the development of modern clinical dermatology was a fact of the first importance in modern clinical dermatology.

 

 

 

Written by: Abdulaziz Mohammed Alqahtani, Medical Student 

 

Reference:

Pusey, William. (1933). The History of Dermatology. (first edition).

Dermatological Manifestations in Patients With SARS-CoV-2.

 

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been initially defined as a disease of the respiratory tract; however, with the increasing number of patients and announcing that the virus became a pandemic, new systemic clinical manifestations are observed, including dermatological manifestations. However, the identification and characteristics of these manifestations are still controversial. This review article aims to evaluate the medical literature and explore the dermatological clinical manifestations in patients with SARS-CoV-2.

 

 

Dermatological lesions are frequent in patients with SARS-CoV-2, especially erythema, urticaria, and varicella-like rash. Differential diagnosis should be thoroughly considered before deciding that the present rash is related to SARS-CoV-2 infections. Till present, the rash is not correlated to the severity of SARS-CoV-2 infection, which needs to be confirmed with studies with a more robust design and larger sample sizes. These findings should be considered by clinicians working with patients with SARS-CoV-2 in order not to misdiagnose the occurrence of dermatological lesions, which may delay therapy or increase the risk of complications.

 

 

Written by: Abdulelah Khalaf Nasser Almutairi, MBBS

 

Reference:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402433

 

Keratosis Pilaris (Chicken Skin)

 

 

 

Keratosis pilaris is a very common inherited condition where small keratotic papules in hair follicles appear as patches of bumps on the skin.  The bumps can be red, white, or darker than the skin.

 

Keratosis pilaris is stealthy in that patients who develop this condition are asymptomatic and it goes unnoticed. The disorder usually affects upper arms, upper legs, and buttocks. Certain age groups have a higher prevalence of this disorder, adolescents to be exact.

 

It is caused by excess keratin in the hair follicles, and although the causes have not been understood, a hormonal influence may be involved considering the high prevalence in adolescents.

 

No cure is available for keratosis pilaris, preventive measures like avoiding excessive skin dryness by moisturizing, staying away from long hot baths, and using mild soaps decrease the symptoms. In severe cases, keratolytic agents such as lactic acid, salicylic acid and urea cream are effective at reducing the appearance.

 

 

 

Written by: Naif Alshaikh, Medical Student 

 

References:

Pediatric dermatology

DermNet NZ

Werewolf syndrome: A brief touch on the different causes of excessive body hair.

 

 

 

 

Hypertrichosis (also known as Werewolf syndrome) is the presence of abnormal amounts of hair on the body in non-androgenic sensitive areas. This needs to be differentiated from hirsutism, which is a condition associated with male-like pattern growth of hair in females, mostly due to endocrine causes.

 

Excess hair growth associated with hypertrichosis may include any hair type (terminal, vellus, and lanugo), this hair growth particularly involves non-androgenic sensitive areas. Congenital form of hypertrichosis is believed to be due to inheritance or a spontaneous mutation. In addition, this form of hypertrichosis is extremely rare, and only a few cases have ever been reported. Furthermore, hypertrichosis could also be acquired and presents in late stages of cancer by an unknown mechanism, this hair growth is termed “malignant down”. However, cancer is not the only cause of the acquired form, it can also be caused by certain medications, such as minoxidil, phenytoin, and cyclosporine. There is not a known cure for the congenital form of hypertrichosis, however, the mainstay of treatment for the acquired form is addressing the culprit and using cosmetic hair removal methods (shaving, waxing, eflornithine cream, etc.).

 

Hypertrichosis is a rare disorder that presents with excessive unwanted hair growth. It could be congenital or acquired, however, the congenital is very rare. Treatment involves treating the underlying cause and using hair removal techniques.

 

 

 

Written by: Khalid Al Dakheel, Medical Student 

 

Resources:

Fitzpatrick’s Color Atlas and Synopsis of Clinical Dermatology, Seventh Edition

https://www.mayoclinic.org/

www.DermNetNZ.org